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M9490019.TXT
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1994-09-03
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Document 0019
DOCN M9490019
TI Smoothing grouped bivariate data to obtain the incubation period
distribution of AIDS.
DT 9411
AU Taylor JM; Chon Y; Department of Biostatistics, UCLA School of Public
Health 90024.
SO Stat Med. 1994 May 15;13(9):969-81. Unique Identifier : AIDSLINE
MED/94323614
AB We use a penalized likelihood approach to obtain a smooth estimate of a
bivariate distribution from grouped data where each observation consists
of a region in a plane. The purpose of the analysis is to estimate the
incubation period distribution of AIDS from the Multicenter AIDS Cohort
Study, a prevalent cohort of homosexual men. In this article we
illustrate the usefulness of the penalized likelihood approach. We also
discuss the use of a cross-validation and a Bayesian scheme to choose
the smoothing parameters and bootstrap samples to assess uncertainty.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/TRANSMISSION AIDS
Serodiagnosis/STATISTICS & NUMER DATA *Cohort Studies Confidence
Intervals Disease Outbreaks/*STATISTICS & NUMER DATA Follow-Up Studies
Homosexuality Human Los Angeles Male *Models, Statistical
Multicenter Studies/*STATISTICS & NUMER DATA Reproducibility of Results
Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).